International Journal of Phonosurgery & Laryngology

Register      Login

VOLUME 2 , ISSUE 2 ( July-December, 2012 ) > List of Articles


Supraglottic Laryngeal Paraganglioma: A Rare Clinical Entity managed by Lateral Pharyngotomy Approach

Citation Information : Supraglottic Laryngeal Paraganglioma: A Rare Clinical Entity managed by Lateral Pharyngotomy Approach. Int J Phonosurg Laryngol 2012; 2 (2):69-73.

DOI: 10.5005/jp-journals-10023-1041

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2012; The Author(s).



Laryngeal paragangliomas are benign slow growing tumors with symptoms resembling squamous cell carcinoma. Hoarseness or dysphasia is the commonest presenting symptom and usually it presents as a submucosal mass on laryngoscopy. A total of 90% of these tumors occur in the supraglottic larynx and the rest in the glottis and the subglottic region. Functional activity is seen in a few (2.9%), none are associated with paraneoplastic syndromes.


Department of Head and Neck Oncosurgery, Kidwai Memorial Institute of Oncology, Bengaluru.

Case report

A 35-year-old male presented to us with hoarseness of voice since 4 months duration. Contrast arteriography demonstrated that the left superior thyroid artery supplied greater than 80% of the blood supply to the laryngeal mass. Superselective embolization was done from the right femoral under local anesthesia and sedation which was uneventful.


The tumor was excised from lateral pharyngotomy approach with an elective tracheostomy. Microscopy suggested it to be paraganglioma and immunohistochemistry confirmed it.


Complete surgical resection or partial laryngectomy with meticulous dissection of surrounding tissues and preservation of neurovascular structures give an excellent prognosis as far as oncological clearance is concerned. Malignant paragangliomas of the larynx are rare and a major meta-analysis is necessary to provide a true biological behavior of this tumor.

How to cite this article

Naik SM. Supraglottic Laryngeal Paraganglioma: A Rare Clinical Entity managed by Lateral Pharyngotomy Approach. Int J Phonosurg Laryngol 2012;2(2): 69-73.

PDF Share
  1. A review of neuroendocrine neoplasms of the larynx: Update on diagnosis and treatment. J Laryngol Otol 1998;112:827-34.
  2. Paraganglioma of the larynx: A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53:220-34.
  3. Benign Paragangliomas: Clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab 2001;86:5210-16.
  4. Paragangliomas of the neck. Arch Surg 1992;127:1441-45.
  5. Paraganglioma of the endolarynx: A rare tumor in an uncommon location. Head Neck Oncol 2010;2:2.
  6. Diagnosis and treatment of supraglottic laryngeal paraganglioma: A case report. Head Neck 2004 Jan;26(1):94-98.
  7. Neuroendocrine tumors of larynx. Ann Otol Rhinol Laryngol 1992;101(8):710-14.
  8. Identification, classification, treatment, and prognosis of laryngeal paraganglioma. Review of the literature and eight new cases. Ann Otol Rhinol Laryngol 1994;103:525-36.
  9. Combined endovascular and surgical treatment of head and neck paragangliomas: A team approach. Head Neck 2002;24:423-31.
  10. Preoperative embolization in the management of neck paragangliomas. Laryngoscope 1997;107:821-26.
  11. Embolization by direct puncture of hypervascularised otorhinolaryngology tumours. Ann Otolaryngol Chir Cervicofac 1994;1111:403-09.
  12. Devascularisation of craniofacial tumours by percutaneous tumour puncture. AJNR Am J Neuroradiol 1994;15:1233-39.
  13. Evolving experience with direct puncture therapeutic embolization for adjunctive and palliative management of head and neck hypervascular neoplasms. Laryngoscope 1999;109:1864-72.
  14. Intratumoral injection of cyanoacrylate glue in head and neck paragangliomas. AJNR Am J Neuroradiol 2004;25:1457-62.
  15. A diagnostic and therapeutic approach to paragangliomas of the larynx. Arch Otolaryngol Head Neck Surg 2001;127:565-69.
  16. The external approach for submucosal lesions of the larynx. Otolaryngol Head Neck Surg 2001;125:370-73.
  17. Surgical approach to submucosal lesions of the supraglottic larynx: The supero-lateral thyrotomy. J Laryngol Oto 1992;106:416-19.
  18. Laryngeal and sinonasal paragangliomas. Otolaryngol Clin North Am 2001;34: 971-82.
  19. Subglottic paraganglioma. Head Neck 1997;19:54-56.
  20. Paragangliomas: Classification, pathology, and differential diagnosis. Otolaryngol Clin North Am 2001;34:845-62.
  21. Radiographic evaluation and assessment of paragangliomas. Otolaryngol Clin North Am 2001;34(5):881-906.
  22. Paraganglioma of the larynx. J Pathol Nepal 2012;2:245-47.
  23. Paragangliomas of the head and neck. Immunohistochemical analysis of 16 cases in comparison with neuro-endocrine carcinomas. Path Res Pract 1991;187:814-23.
  24. Paraganglioma of the larynx: A case report. IJMS 2004;29: 47-49.
  25. Neuroendocrine neoplasms of the larynx: An overview. Head Neck 2009 Dec;31(12):1634-46.
  26. Review: Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes? J Clin Endocrinol Metab 2006;91(8):2851-58.
  27. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA 2004;292(8):943-51.
  28. Laryngeal paraganglioma in a patient with multiple head and neck paragangliomas. Otolaryngol Head Neck Surg 2005;132(3):520-22.
  29. Chemodectoma of the larynx; A case report. AMA Arch Otolaryngol 1955;61(4):472-74.
  30. Paragangliomas of the jugular bulb and carotid body: MR imaging with short sequences and Gd- DPTA enhancement. AJR 1989;153:583-87.
  31. MRI screening of kindred at risk of developing paragangliomas: Support for genomic imprinting in hereditary glomus tumours. Br J Cancer 1992;65:903-07.
  32. Glomus tumors of the skull base: Combined use of MR angiography and spin-echo imaging. Radiology 1994;192: 103-10.
  33. Vascularization of head and neck paragangliomas: Comparison of three angiographic techniques with digital subtraction angiography. AJNR 2000;21:162-70.
  34. Laryngeal paraganglioma: An updated critical review. Acta Otolaryngol 2004;124(9):995-99.
  35. Vocal cord paralysis following percutaneous embolization of a vagal paraganglioma. Int J Head Neck Surg 2011 Jan-Apr;2(1):65-66.
  36. Intratumoral embolization of intracranial and extracranial tumors: Technical note. Neurosurgery 1994;35:771-73.
  37. Relapsing paraganglioma of the inferior laryngeal paraganglion: Case report and review of the literature. Head Neck 2002;24(1):95-102.
  38. Laryngeal paraganglioma versus atypical carcinoid tumor. Ann Otol Rhinol Laryngol 1995;104:78-83.
  39. Extra-adrenal paraganglioma: Carotid body, jugulotympanic, vagal, laryngeal, aortico-pulmonary. In: DeLellis, Lloyd RV, Heitz PU, Eng C (Eds). Pathology and genetics. Tumors of endocrine organs. Lyon: IARC Press 2004;16.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.