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VOLUME 8 , ISSUE 1 ( January-June, 2018 ) > List of Articles


Primary Laryngeal Amyloidosis: A Discussion of 10 Cases with a Review of the Literature

Arundhatee P Sapre, Rahul S Gosavi

Keywords : Benign laryngeal tumor, Larngeal amyloidosis, Primary amyloidosis

Citation Information : Sapre AP, Gosavi RS. Primary Laryngeal Amyloidosis: A Discussion of 10 Cases with a Review of the Literature. Int J Phonosurg Laryngol 2018; 8 (1):52-60.

DOI: 10.5005/jp-journals-10023-1159

License: CC BY-NC 3.0

Published Online: 01-03-2019

Copyright Statement:  Copyright © 2018; The Author(s).


Primary laryngeal amyloidosis is rare, accounting for 0.2 to 1.2 % of its benign tumors. However, it is the most common site in the upper aerodigestive tract for isolated primary amyloidosis. The most common symptom is hoarseness of voice, and depending on the extent of involvement, it may present with varying degrees of breathlessness. Diagnosis requires accurate histopathology using special staining by Congo red stain which demonstrates the typical apple-green birefringence when seen under polarized light. Diagnosis is often missed in the absence of special stains. Treatment requires as complete an excision as possible preferably with a laser. Periodic follow-ups are needed for the detection of recurrences. We present a series of 10 patients with primary laryngeal amyloidosis attending the voice clinic from March 2011 to February 2018, with a discussion of their management and a review of literature.

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  1. Behnoud F, Baghbanian N. Isolated laryngeal amyloidosis. Iranian journal of otorhinolaryngology. 2013;25(70): 49.
  2. Mitrani M, Biller HF. Laryngeal amyloidosis. The Laryngoscope. 1985 Nov;95(11):1346-1347.
  3. Saha KL, Datta PG, Dutta UK, Rahman AK, Akhter S. Primary Amyloidosis of Larynx A Case Report. Bangladesh Journal of Otorhinolaryngology. 2015;20(2):93-97.
  4. Dabholkar JP, More M, Avanindra K, Sharma A. Primary exophytic laryngeal amyloidosis presenting as sudden airway obstruction. Indian Journal of Otolaryngology and Head & Neck Surgery. 2007 Dec 1;59(4):357-359.
  5. Hellquist H, Olofsson J, Sökjer H, Ödkvist LM. Amyloidosis of the larynx. Acta oto-laryngologica. 1979 Jan 1;88(1-6):443-450.
  6. Almuslim HM, Alshaikh NA. Extensive laryngeal amyloidosis presenting with stridor: Review of literature and case presentation. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2014 Mar 1;15(1):41-44.
  7. Salman R, Lateef M, Iqbal I, Rehman A, ul Islam M. Laryngeal amyloidosis: a case report. Indian Journal of Otolaryngology and Head & Neck Surgery. 2011 Jan 1;63(1):85-86.
  8. Siddachari RC, Chaukar DA, Pramesh CS, Naresh KN, de Souza CE, Dcruz AK. Laryngeal amyloidosis. Journal of otolaryngology. 2005 Jan 1;34(1):60-63.
  9. Thompson LD, Derringer GA, Wenig BM. Amyloidosis of the larynx: a clinicopathologic study of 11 cases. Modern Pathology. 2000 May;13(5):528.
  10. Nerurkar NK. Amyloidosis. In: Nupur K Nerurkar ed. Atlas of phonomicrosurgery, Jaypee publications, Chapter 16,117.
  11. New GB. Amyloid tumors of the upper air passages. The Laryngoscope. 1919 Jun;29(6):327-341.
  12. Passerotti GH, Caniello M, Hachiya A, Santoro PP, Imamura R, Tsuji DH. Multiple-sited amyloidosis in the upper aerodigestive tract: case report and literature review. Revista Brasileira de Otorrinolaringologia. 2008 Jun;74(3):462-466.
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