Introduction: Change in voice in the patient of laryngopharyngeal reflux is a common symptom. In this study, we are assessing the improvement in severity of the laryngopharyngeal reflux disease by its symptoms, signs, severity, and videostroboscopy to detect even earliest change and document it.
Materials and methods: A prospective study in 50 subjects at a tertiary referral center who were subjected to answer a questionnaire of the voice handicap index, the reflux symptom index, and assessed reflux finding score and vocal fold mucosa changes by videostroboscopy. All subjects were reassessed after 12 weeks of treatment.
Result: Improvement was found statistically significant (<0.05) in all parameters and scales.
Conclusion: Preventing the insult by acid reflux in the laryngeal mucosa by proton pump inhibitors resulted in improvement of symptoms and signs, which proves the efficacy of treatment. Videostroboscopy is a useful tool to early diagnose the lesion.
Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux. Laryngoscope 2001;111(8):1313–1317. DOI: 10.1097/00005537-200108000-00001.
Lechien JR, Huet K, Khalife M, et al. Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study. J Otolaryngol Head Neck Surg [Internet] 2016;45(1):59. DOI: 10.1186/s40463-016-0171-1Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101798/.
Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16(2):274–277. DOI: 10.1016/s0892-1997(02)00097-8.
Park KH, Choi SM, Kwon SUK, et al. Diagnosis of laryngopharyngeal reflux among globus patients. Otolaryngol Head Neck Surg 2006;134(1):81–85. DOI: 10.1016/j.otohns.2005.08.025.
Jin BJ, Lee YS, Jeong SW, et al. Change of acoustic parameters before and after treatment in laryngopharyngeal reflux patients. Laryngoscope 2008;118(5):938–941. DOI: 10.1097/MLG.0b013e3181651c3a.
Masaany M, Marina MB, Sharifa Ezat WP, et al. Empirical treatment with pantoprazole as a diagnostic tool for symptomatic adult laryngopharyngeal reflux. J Laryngol Otol 2011;125(5):502–508. DOI: 10.1017/S0022215111000120.
Naiboglu B, Durmus R, Tek A, et al. Do the laryngopharyngeal symptoms and signs ameliorate by empiric treatment in patients with suspected laryngopharyngeal reflux? Auris Nasus Larynx 2011;38(5):622–627. DOI: 10.1016/j.anl.2011.01.010.
Chun B-J, Lee D-S. The effect of itopride combined with lansoprazole in patients with laryngopharyngeal reflux disease. Eur Arch Otorhinolaryngol 2013;270(4):1385–1390. DOI: 10.1007/s00405-012-2341-8.
Siupsinskiene N, Adamonis K, Toohill RJ. Quality of life in laryngopharyngeal reflux patients. Laryngoscope 2007;117(3): 480–484. DOI: 10.1097/MLG.0b013e31802d83cf.
Book DT, Rhee JS, Toohill RJ, et al. Perspectives in laryngopharyngeal reflux: an international survey. Laryngoscope 2002;112(8):1399–1406. DOI: 10.1097/00005537-200208000-00014.
Beaver ME, Stasney CR, Weitzel E, et al. Diagnosis of laryngopharyngeal reflux disease with digital imaging. Otolaryngol Head Neck Surg 2003;128(1):103–108. DOI: 10.1067/mhn.2003.10.
Raghunandhan S, Nagasundaram J, Natarajan K, et al. Videostroboscopy in laryngopharyngeal reflux disorder. Murthy P, ed. Int J Phonosurg Laryngol 2011;1(2):52–56. DOI: 10.5005/jp-journals-10023-1013.