Introduction: The laryngopharyngeal reflux (LPR) is defined as the retrograde flow of gastric contents to the upper respiratory tract causing mucosal damage. Objectives: The study aims to determine the relationship between the incidence of LPR and the presence of benign lesions of the vocal folds. Materials and methods: Using the reflux finding score (RFS), we determined the incidence of the LPR in patients with changes such as Reinke's edema, polyps, and granulomas of the vocal folds. Results: The prevalence of pathologic LPR was 25% in the control group, 81% in the Reinke's edema group, 60% in the vocal folds granulomas group, and 41% in the vocal cord polyps group. The most common manifestation of the LPR in the videolaryngoscopic examination is hypertrophy of the posterior commissure, which is anatomically explained by the closest location to the esophagus. Conclusion: In conclusion, the LPR might be an etiologic factor in Reinke's edema, polyps, and granulomas of the vocal folds.
Skrzypczak W. Inflammatory and neoplastic lesions of the laryngeal mucosa in gastroesophageal reflux disease. Otolaryngol Pol 2011;65(1):66–67. DOI: 10.1016/S0030-6657(11)70631-X.
Witt DR, Chen H, Mielens JD, et al. Detection of chronic laryngitis due to laryngopharyngeal reflux using color and texture analysis of laryngoscopic images. J Voice 2014;28(1):98–105. DOI: 10.1016/j.jvoice.2013.08.015.
Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA 2005;294(12):1534–1540. DOI: 10.1001/jama.294.12.1534.
Campagnolo AM, Priston J, Thoen RH, et al. Laryngopharyngeal reflux: diagnosis, treatment, and latest research. Int Arch Otorhinolaryngol 2014;18(2):184–191. DOI: 10.1055/s-0033-1352504.
Habermann W, Schmid C, Neumann K, et al. Reflux symptom index and reflux finding score in otolaryngologic practice. J Voice 2012;26(3):e123–e127. DOI: 10.1016/j.jvoice.2011.02.004.
Lai Y-C, Wang P-C, Lin J-C. Laryngopharyngeal reflux in patients with reflux esophagitis. World J Gastroenterol 2008;14(28):4523–4528. DOI: 10.3748/wjg.14.4523.
Chung JH, Tae K, Lee YS, et al. The significance of laryngopharyngeal reflux in benign vocal mucosal lesions. Otolaryngol Head Neck Surg 2009;141(3):369–373. DOI: 10.1016/j.otohns.2009.05.033.
Tsunoda K, Ishimoto S, Suzuki M, et al. An effective management regimen for laryngeal granuloma caused by gastro-esophageal reflux: combination therapy with suggestions for lifestyle modifications. Acta Otolaryngol 2007;127(1):88–92. DOI: 10.1080/00016480600606 665.