Plasma cell Neoplasms, Plasmacytoma with amyloidosis,Extramedullary plasmacytomas
Citation Information :
Nerurkar N, Gala S, Shah R, Mittal U. Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review. Int J Phonosurg Laryngol 2018; 8 (2):79-82.
Extramedullary plasmacytomas (EMP) are rare malignant plasma cell neoplasms (PCNs) mainly affecting the head and the neck region. These are more commonly seen in adult males. These have variable outcomes and may even coexist with, or progress to multiple myelomas (MMs). Hence, a systemic examination is a must, to rule out generalized involvement. The presence of monoclonal plasma cells on histopathology explains the relationship of PCNs with amyloidosis. Treatment may be surgical for accessible tumors or low to moderate dose radiation as indicated. Long-term surveillance is a must. We discuss two cases of extramedullary PCNs with amyloidosis involving the head–neck region. Both the patients underwent surgical excision followed by radiation for the residual disease and recurrence prevention. Systemic involvement was ruled out and the patients have been advised regular follow-up.
Gholizadeh N, Mehdipour M, et al. Extramedullary Plasmacytoma of the Oral Cavity in a Young Man: A Case Report. J Dent Shiraz Univ Med Sci 2016 June;17(2):155–158.
Majumdar S, Raghavan U, et al. Solitary plasmacytoma and extramedullary plasmacytoma of the paranasal sinuses and soft palate. J Laryngol Otol 2002;116:962–965. DOI: 10.1258/00222150260369561.
Anil S. Solitary plasmacytoma of the maxilla–a case report and review of the literature. Gen Dent 2007;55:39–43.
Sharma N, Sharma S, et al. Plasmacytoma with amyloidosis masquerding as tuberculosis on cytology. J Cytol 2009 Oct–Dec;26(4):161–163. DOI: 10.4103/0970-9371.62190.
Nagasaka T, Lai R, et al. Localized amyloidosis and extramedullary plasmacytoma involving the larynx of a child. Hum Pathol 2003;32:132–134. DOI: 10.1053/hupa.2001.20896.
Kwon D, Myoung H. Case Report: Extramedullary Plasmacytoma of Soft Palate. Korean J Oral Maxillofac Pathol 2016;40(3):832–838. DOI: 10.17779/KAOMP.2016.40.3.005.
Kapadia SB, Desai U, et al. Extramedullary Plasmacytoma of the Head and Neck: A Clinicopathologic Study of 20 Cases. Medicine (Baltimore) 1982;61:317–329. DOI: 10.1097/00005792-198209000-00004.
Mendenhall WM, Charles MM, et al. Solitary plasmacytoma of bone and soft tissues. Am J Otolaryngol 2003;24:395–399. DOI: 10.1016/S0196-0709(03)00092-9.
Neville BW, Damm DD, et al. Oral and maxillofacial pathology. Philadelphia Saunders 2008;606–607.
Rawat DS, Grover M, et al. Extramedullary Plasmacytoma of Nasal Cavity: A Rare Entity. Clinical Rhinology: An International Journal 2010;3:39–41. DOI: 10.5005/jp-journals-10013-1025.
Yoshimura Y, Takada K, et al. Two cases of plasmacytoma in the oral cavity. Int J Oral Surg 1976 Apr;5(2):82–91.
dos Anjos Corvo MA, Granato L, et al. Extramedullary nasal plasmacytoma: literature review and a rare case report. Int Arch Otorhinolaryngol 2013;17(2):213–217. DOI: 10.7162/S1809-97772013000200016.
Dalal B S, Sarkar P, et al. Soft-tissue amyloidoma with associated plasmacytoma. Indian Journal of Pathology and Microbiology Oct–Dec 2016;59(4):535–537. DOI: 10.4103/0377-4929.191821.
Zuo Z, Tang Y, et al. Ex traosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases. Diagn Pathol 2011;6:123. DOI: 10.1186/1746-1596-6-123.
Krishnan J, Chu WS, et al. Tumoral presentation of amyloidosis (amyloidomas) in soft tissues: a report of 14 cases. Am J Clin Pathol 1993;100:135–144. DOI: 10.1093/ajcp/100.2.135.
Pambuccian SE, Horyd ID, et al. Amyloidoma of bone, a plasma cell/plasmacytoid neoplasm: report of three cases and review of the literature. Am J Surg Pathol 1997;21:179–186. DOI: 10.1097/00000478-199702000-00007.
Eilam O, Liepnieks JJ, et al. Plasmacytoma of the nasal cavity with lambda III amyloid deposition. Amyloid 1995;2:31–35. DOI: 10.3109/13506129509031885.
Ustün MO, Ekinci N, et al. Extramedullary plasmacytoma of the parotid gland. report of a case with extensive amyloid deposition masking the cytologic and histopathologic picture. Acta Cytol 2001;45:449–453. DOI: 10.1159/000327648.
Huoh KC, Van Zante A, et al. Case Report: Extramedullary Plasmacytoma of the Tonsil. Case Rep Otolaryngol 2011;2011:430809. DOI: 10.1155/2011/430809.
Bachar G, Goldstein D, et al. Solitary extramedullary plasmacytoma of the head and neck—Long-term outcome analysis of 68 cases. Head and Neck 2008;30(no. 8):1012–1019. DOI: 10.1002/hed.20821.
Cytawa W, Jacek T, et al. Nuclear Imaging of Amyloidosis. Pol J Radiol 2014;79:222–227. DOI: 10.12659/PJR.890147.
Wiltshaw E. The natural history of extramedullary plasmocitoma and its relation to solitary mieloma of bone and myelomatosis. Medicine 1976;55:217–238. DOI: 10.1097/00005792-197605000-00002.