Citation Information :
Zahir ST, Rahmani K, Mehri M, Shafiee M, Mortazavizadeh SM. Clinicopathological Characteristics and Survival Rate of Patients with Laryngeal Squamous Cell Carcinoma: A Retrospective Study during 2011–2017 in Yazd, Iran. Int J Phonosurg Laryngol 2018; 8 (2):65-70.
Background: The aim of the current study is to determine the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma and evaluation of the effect of prognostic factors on survival rate.
Materials and methods: The archives of all patients with laryngeal squamous cell carcinoma (2011–2017) were studied. Patients’ data were extracted using a checklist that included age, gender, tumor stage, treatment methods used, and survival rate in months. All data were analyzed by the SPSS-17 software with the Chi-square test, the Kaplan–Meier test, and the log-rank test at a statistical significance level of p < 0.05.
Results: Out of 109 patients with laryngeal cancer, 99 were males and 10 were females. Patients in stages I and II and also in stage III had a longer overall survival compared to patients in stage IV. The mean survival rate was found to be significantly lower in patients in stage IV compared to those in the other stages of the disease. Patients in the age group of 35–59 years had a longer overall survival compared to the older age group (60–89 years). Patients at stage III of the disease who had not undergone chemotherapy had a greater longevity compared to the ones who had undergone the therapy. Patients at stage IV who had not undergone laryngectomy had a much lower survival rate compared to those who had used both surgery and radiotherapy or chemoradiation.
Conclusion: Surgery and radiotherapy can positively affect the mean survival rate in patients at stages I and II of laryngeal carcinoma. Together surgery and chemotherapy or chemoradiation have a positive effect on the survival of patients in advanced stages of the disease.
Reiter R, Hoffmann TK, et al. Hoarseness-causes and treatments. Dtsch Ärztebl Int 2015;112(19):329–337. DOI: 10.3238/arztebl.2015.0329.
Schultz P. Vocal fold cancer. Eur Ann Otorhinolaryngol Head Neck Dis 2011;128(6):301–308. DOI: 10.1016/j.anorl.2011.04.004.
Mau T. Diagnostic evaluation and management of hoarseness. Med Clin North Am 2010;94(5):945–960. DOI: 10.1016/j.mcna.2010.05.010.
Luke CG, Yeoh E, et al. Exploring trends in laryngeal cancer incidence, mortality and survival: implications for research and cancer control. Asian Pac J Cancer Prev 2008;9(3):397–402.
Chatenoud L, Garavello W, et al. Laryngeal cancer mortality trends in European countries. Int J Cancer 2015;138(4):833–842.
Howlader N, Noone AM, et al. SEER Cancer Statistics Review, 1975–2011. Bethesda, MD: National Cancer Institute; April 2014. http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site.
Howlader N, Noone AM, et al. SEER Cancer Statistics Factsheets: Larynx Cancer, 1975–2011. Bethesda, MD: National Cancer Institute; April 2014. http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site.
Kolahdoozan S, et al. Five common cancers in Iran. Arch Iran Med 2010;13(2):143–146.
Mafi N, Kadivar M, et al. Head and neck squamous cell carcinoma in Iranian patients and risk factors in young adults: a fifteen-year study. Asian Pac J Cancer Prev 2012;13(7):3373–3378. DOI: 10.7314/APJCP.2012.13.7.3373.
Saedi B, Razmpa E, et al. The epidemiology of laryngeal cancer in a country on the esophageal cancer belt. Indian J Otolaryngol 2009;61(3):213–217. DOI: 10.1007/s12070-009-0069-6.
Risks and causes of laryngeal cancer, Cancer Research UK: http://www.cancerresearchuk.org/about-cancer/type/larynx-cancer/about/risks-and causes-of-laryngeal-cancer, May 26, 2015.
Grenman R, Koivunen P, et al. Laryngeal cancer in Finland. Duodecim 2015;131(4):331–337.
Al-Mamgani A, Tans L, et al. A single-institutional experience of 15 years of treating T3 laryngeal cancer with primary radiotherapy, with or without chemotherapy. Int J Radiat Oncol Biol Phys 2012;83(3):1000–1006. DOI: 10.1016/j.ijrobp.2011.07.045.
Chen AY, Fedewa S, et al. Improved survival is associated with treatment at high-volume teaching facilities for patients with advanced stage laryngeal cancer. Cancer 2010;116(20):4744–4752. DOI: 10.1002/cncr.25364.
Doornaert P, Terhaard CH, et al. Dutch National Platform Radiotherapy H, Neck C. Treatment of T3 laryngeal cancer in the Netherlands: a national survey. Radiat Oncol 2015;10:134. DOI: 10.1186/s13014-015-0440-6.
Timmermans AJ, de Gooijer CJ, et al. T3–T4 laryngeal cancer in The Netherlands Cancer Institute; 10-year results of the consistent application of an organ-preserving/-sacrificing protocol. Head Neck 2015;37(10):1495–1503. DOI: 10.1002/hed.23789.
Dziegielewski PT, O'Connell DA, et al. Primary total laryngectomy versus organ preservation for T3/T4a laryngeal cancer: a population-based analysis of survival. J Otolaryngol 2012;41(Suppl 1):S56–S64.
MacNeil SD, Liu K, et al. Secular trends in the survival of patients with laryngeal carcinoma, 1995–2007. Curr Oncol 2015;22(2):e85–e99. DOI: 10.3747/co.22.2361.
National Comprehensive Cancer Network, Inc. 2014, Available at http://www.nccn.org. May 12, 2013.
Warner L, Chudasama J, et al. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev 2014;12:CD002027. DOI: 10.1002/14651858.CD002027.pub2.
Qin J, Wang H, et al. Small partial laryngectomy without tracheotomy for T1-2 stage glottic carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2014;28(16):1272–1274.
Forastiere AA, Goepfert H, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349(22):2091–2098. DOI: 10.1056/NEJMoa031317.
Ganly I, Patel SG, et al. Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck 2009;31(11):1489–1495.
Caicedo-Granados E, Beswick DM, et al. Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer. Otolaryngol Head Neck Surg 2013;148(2):235–242. DOI: 10.1177/0194599812466367.
Gourin CG, Conger BT, et al. The effect of treatment on survival in patients with advanced laryngeal carcinoma. The Laryngoscope 2009;119(7):1312–1317. DOI: 10.1002/lary.20477.
Rosenthal DI, Mohamed AS, et al. Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: A 3-decade survey. Cancer 2015;121(10):1608–1619. DOI: 10.1002/cncr.29241.
Lai FY, Zhang Q, et al. Treatment and prognosis of stage IV glottic laryngeal cancer. Chinese J Cancer Res 2008;27(1):71–74.
Lim YJ, Wu HG, et al. Long-Term Outcome of Definitive Radiotherapy for Early Glottic Cancer: Prognostic Factors and Patterns of Local Failure. Cancer Res Treat 2015;47(4):862–870. DOI: 10.4143/crt.2014.203.
Levy A, Blanchard P, et al. Squamous cell carcinoma of the larynx with subglottic extension: is larynx preservation possible? Strahlenther Onkol 2014;190(7):654–660. DOI: 10.1007/s00066-014-0647-8.
Harada A, Sasaki R, et al. Treatment outcomes of the patients with early glottic cancer treated with initial radiotherapy and salvaged by conservative surgery. Jpn J Clin Oncol 2015;45(3):248–255. DOI: 10.1093/jjco/hyu203.
Stankovic M, Milisavljevic D, et al. Primary and salvage total laryngectomy. Influential factors, complications, and survival. J BUON 2015;20(2):527–539.