International Journal of Phonosurgery & Laryngology

Register      Login

VOLUME 3 , ISSUE 2 ( July-December, 2013 ) > List of Articles


Plexiform Neurofibroma of the Larynx: A Challenging Management Dilemma

Gauri Kapre

Citation Information : Kapre G. Plexiform Neurofibroma of the Larynx: A Challenging Management Dilemma. Int J Phonosurg Laryngol 2013; 3 (2):55-57.

DOI: 10.5005/jp-journals-10023-1063

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2013; The Author(s).



Among the many causes responsible for stridor in the pediatric population, tumors of the larynx are relatively rare. Rarer still is the presence of endolaryngeal neurofibromas. Plexiform neurofibromas are associated with type I neurofibromatosis (NF1). Their typical characteristic is that they are diffuse tumors with indistinct margins, which makes complete resection a challenge and the chances of recurrences higher.


To document our experience with endolaryngeal neurofibromas and to discuss the treatment options available for this rare condition.


We present two cases of plexiform neurofibromas in pediatric patients. Both children presented with large supraglottic masses which interfered with breathing and swallowing. They also fulfilled the criteria for type I neurofibroma. Endolaryngeal approach with microdebrider and laser-assisted surgical excision was performed in both cases.


Following surgery, both patients had uneventful recovery and no subsequent breathing or swallowing difficulties.


The dilemma in the management of endolaryngeal neurofibroma is the choice between endolaryngeal laser and aggressive external approach surgery. A short review of the limited existing literature shows that it is wiser to limit the surgery to as complete a resection as is possible endoscopically.

How to cite this article

Nerurkar NK, Kapre G. Plexiform Neurofibroma of the Larynx: A Challenging Management Dilemma. Int J Phonosurg Laryngol 2013;3(2):55-57.

PDF Share
  1. Management of Head and Neck Plexiform Neurofibromas in Pediatric Patients with Neurofibromatosis Type 1. Arch Otolaryngol Head Neck Surg 2005;131:712-718.
  2. Diagnostic evaluation of multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51-57.
  3. The Biology and Management of Laryngeal Neurofibroma. Arch Otolaryngol Head Neck Surg 2004;130:1400-1406.
  4. Management of advanced laryngeal and hypopharyngeal plexiform neurofibroma in adults. Am J Otolaryngol Head and Neck Medicine and Surgery 2008;29:279-283.
  5. Malignant nerve sheath tumors. Cancer 1986;57:2006-2021.
  6. Prognostic signs in the surgical management of plexiform neurofibroma: the Childrens’ Hospital of Philadelphia Experience, 1974-1994. J Pediatr 1997;131:678-682.
  7. Laryngeal neurofibroma: case report of a child. Int J Pediatr Otorhinolaryngol 2002;65:167-170.
  8. Airway obstruction in children due to plexiform neurofibroma of the larynx. J Laryngol and Otol 1996 Nov;110:1065-1068.
  9. Endolaryngeal Neurofibromas. Otolaryngol Head Neck Surg 1980;88:74-78.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.