International Journal of Phonosurgery & Laryngology

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VOLUME 2 , ISSUE 1 ( January-June, 2012 ) > List of Articles


Laryngopharyngeal Reflux: Prospective Study Analyzing Various Nonsurgical Treatment Modalities for LPR

Owais Mattoo, Aamir Yousuf, Anees Mir, Rahil Muzaffar, Rauf Ahmad, Aakib Hamid Charag

Citation Information : Mattoo O, Yousuf A, Mir A, Muzaffar R, Ahmad R, Charag AH. Laryngopharyngeal Reflux: Prospective Study Analyzing Various Nonsurgical Treatment Modalities for LPR. Int J Phonosurg Laryngol 2012; 2 (1):5-8.

DOI: 10.5005/jp-journals-10023-1026

Published Online: 01-06-2015

Copyright Statement:  Copyright © 2012; The Author(s).



To compare the outcomes of various medical treatment modalities for laryngopharyngeal reflux (LPR).

Study design

Prospective study design.

Materials and methods

One-hundred and fifty patients were divided into three groups (A, B, C) based on the mode of intervention used for the control of LPR. Each study group enrolled 50 patients using random tables.

• Group A: These patients were put on a twice daily dosage of esomeprazole (20 mg bd) and domeperidone (10 mg bd) for 4 months

• Group B: These patients were put on bd dosage of esomeprazole (20 mg) and domeperidone (10 mg) and also received counseling for dietary and lifestyle changes. The duration of treatment was for 4 months.

• Group C: These patients received, in addition to above, 10 mg of amitriptyline (tricyclic antidepressant) bid, again for 4 months.


The success achieved in controlling LPR was defined as greater than 50% improvement in baseline symptoms. The success achieved in group A was 46%, in group B was 54% and in group C was 40%.

The relative change in reflux symptom index (RSI) over any given period of time was significantly higher than the relative change in reflux finding score (RFS). The relative change in RSI over first month was 30.99%, which is significantly higher than the relative change of RFS (6.39%) over the same period.

The mean RSI scores during 4 months of treatment fell from 20.67 to 8.9 (p < 0.01) in group A, from 23.3 to 8.6 (p < 0.01) and from 21.3 to 10.8 (p < 0.05) in group C.

The mean RFS during 4 months fell from 15 to 6.5 (p < 0.05) in group A, from 16 to 6.4 (p < 0.05) and from 15 to 6.4 (p < 0.05) in group C.


• All the three interventions had a statistically significant impact on the signs and symptoms of LPR.

• However, higher success rates were achieved in group B where patients were put on a bid dosage esomeprazole and domeperidone nad counseled for lifestyle and dietary changes. Paradoxically, success rates achieved in group C was lower than other groups, possibly because of the anticholinergic effects of amitriptyline causing dry mouth and dry throat.

• The symptomatic improvement was seen much earlier than the improvement in laryngoscopic findings. This was evidenced by the fact that relative change in RSI was much higher than the relative change of RFS over a given period of time.

• If diagnosed with enough surety and certainty, patients of LPR do not need any antidepressant medications as these medications may not have any role in the treatment of same and may, however, worsen the condition owing to their anticholinergic side effects.

How to cite this article

Mattoo O, Muzaffar R, Mir A, Yousuf A Charag AH, Ahmad R. Laryngopharyngeal Reflux: Prospective Study Analyzing Various Nonsurgical Treatment Modalities for LPR. Int J Phonosurg Laryngol 2012;2(1):5-8.

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